In addition to the Ministry of Economic Growth and Job Creation and the provisions of the NWC Act, the National Water Commission is regulated in different areas and to different degrees by a number of different entities.

The island's surface and sub-surface water resources are regulated by the Water Resources Authority (WRA) which is the agency established by statute for this purpose. Other bodies that regulate the NWC are the Office of Utilities Regulation (OUR), the Ministry of Health, National Environment and Planning Agency (NEPA), the Jamaica Bureau of Standards, the Ministry of Labour, and the Factories Act.